Publications

Welcome to Dr. Simon Kaja's Research Pages

Peer-reviewed articles

Books & book chapters

Abstracts

Courses

Peer-reviewed publications

2012:

• Kaja S, Mafe OA, Parikh RA, Kandula P, Reddy CA, Gregg EV, Xin H, Mitchell P, Grillo MA, Koulen P. Distribution and function of polycystin-2 in mouse retinal ganglion cells. Neuroscience. in press. NIHMSID # 342441

• Burroughs SL, Duncan RS, Rayudu P, Kandula P, Payne AJ, Clark JL, Koulen P, Kaja S. Plate reader-based assays for measuring cell viability, neuroprotection and calcium in primary neuronal cultures. J Neurosci Methods. 2012;203(1):141-52011. PMCID: 3221776

2011:

• Kaja S, Hilgenberg JD, Everett E, Olitsky SE, Gossage J, Koulen P. Effects of dilution and prolonged storage with preservative in a polyethylene container on Bevacizumab (Avastin™) for topical delivery as a nasal spray in anti-hereditary hemorrhagic telangiectasia and related therapies. Hum Antibodies. 2011;20(3):95-101. NIHMSID # 345666

• Kaja S, Hilgenberg JD, Rybalchenko V, Medina-Ortiz WE, Gregg EV, Koulen P. Polycystin-2 expression and function in adult mouse lacrimal acinar cells. Invest Ophthalmol Vis Sci. 2011;52(8):5605-11. PMCID: 3176037.

• Burroughs SL, Kaja S, Koulen P. Quantification of deficits in spatial visual function of mouse models for glaucoma. Invest Ophthalmol Vis Sci. 2011;52(6):3654-9. PMCID: 3109046.

• Garg P, Duncan RS, Kaja S, Zabaneh A, Chapman KD, Koulen P. Lauroylethanolamide and linoleoylethanolamide improve functional outcome in a rodent model for stroke. Neurosci Lett. 2011;492(3):134-8. PMCID: 3057422.

• Kaja S, Duncan RS, Longoria S, Hilgenberg JD, Payne AJ, Desai NM, Parikh RA, Burroughs SL, Gregg EV, Goad DL, Koulen P. Novel mechanism of increased Ca(2+) release following oxidative stress in neuronal cells involves type 2 inositol-1,4,5-trisphosphate receptors. Neuroscience. 2011;175:281-91. PMCID: 3038464.

2010:

• Kaja S, Van de Ven RC, Broos LA, Frants RR, Ferrari MD, Van den Maagdenberg AM, Plomp JJ. Severe and progressive neurotransmitter release aberrations in familial hemiplegic migraine type 1 Cacna1a S218L knock-in mice. J Neurophysiol. 2010;104(3):1445-55.

• Duncan RS, Goad DL, Grillo MA, Kaja S, Payne AJ, Koulen P. Control of intracellular calcium signaling as a neuroprotective strategy. Molecules. 2010;15(3):1168-95. PMCID: 2847496.

• van den Maagdenberg AM *, Pizzorusso T *, Kaja S *, Terpolilli N *, Shapovalova M, Hoebeek FE, Barrett CF, Gherardini L, van de Ven RC, Todorov B, Broos LA, Tottene A, Gao Z, Fodor M, De Zeeuw CI, Frants RR, Plesnila N, Plomp JJ, Pietrobon D, Ferrari MD. High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice. Ann Neurol. 2010;67(1):85-98.

• Garg P, Duncan RS, Kaja S, Koulen P. Intracellular mechanisms of N-acylethanolamine-mediated neuroprotection in a rat model of stroke. Neuroscience. 2010;166(1):252-62. PMCID: 2830814.

2009:

• Plomp JJ, van den Maagdenberg AM, Kaja S. The ataxic Cacna1a-mutant mouse rolling nagoya: an overview of neuromorphological and electrophysiological findings. Cerebellum. 2009;8(3):222-30. PMCID: 2734259.

2008:

• Kaja S, Van De Ven RC, Frants RR, Ferrari MD, Van Den Maagdenberg AM, Plomp JJ. Reduced ACh release at neuromuscular synapses of heterozygous leaner Ca(v)2.1-mutant mice. Synapse. 2008;62(5):337-44.

2007:

• Kaja S, Hann V, Payne HL, Thompson CL. Aberrant cerebellar granule cell-specific GABAA receptor expression in the epileptic and ataxic mouse mutant, Tottering. Neuroscience. 2007;148(1):115-25.

• van de Ven RC, Kaja S, Plomp JJ, Frants RR, van den Maagdenberg AM, Ferrari MD. Genetic models of migraine. Arch Neurol. 2007;64(5):643-6.

• Kaja S, van de Ven RC, van Dijk JG, Verschuuren JJ, Arahata K, Frants RR, Ferrari MD, van den Maagdenberg AM, Plomp JJ. Severely impaired neuromuscular synaptic transmission causes muscle weakness in the Cacna1a-mutant mouse rolling Nagoya. Eur J Neurosci. 2007;25(7):2009-20.

• Kaja S, Todorov B, van de Ven RC, Ferrari MD, Frants RR, van den Maagdenberg AM, Plomp JJ. Redundancy of Cav2.1 channel accessory subunits in transmitter release at the mouse neuromuscular junction. Brain Res. 2007;1143:92-101.

• Kaja S, van de Ven RC, Broos LA, Frants RR, Ferrari MD, van den Maagdenberg AM, Plomp JJ. Characterization of acetylcholine release and the compensatory contribution of non-Ca(v)2.1 channels at motor nerve terminals of leaner Ca(v)2.1-mutant mice. Neuroscience. 2007;144(4):1278-87.

2004-2006:

• Todorov B, van de Ven RC, Kaja S, Broos LA, Verbeek SJ, Plomp JJ, Ferrari MD, Frants RR, van den Maagdenberg AM. Conditional inactivation of the Cacna1a gene in transgenic mice. Genesis. 2006;44(12):589-94.

• Kaja S, Van de Ven RC, Ferrari MD, Frants RR, Van den Maagdenberg AM, Plomp JJ. Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice. J Neurophysiol. 2006;95(4):2698-704.

• Kaja S, van de Ven RC, Broos LA, Veldman H, van Dijk JG, Verschuuren JJ, Frants RR, Ferrari MD, van den Maagdenberg AM, Plomp JJ. Gene dosage-dependent transmitter release changes at neuromuscular synapses of CACNA1A R192Q knockin mice are non-progressive and do not lead to morphological changes or muscle weakness. Neuroscience. 2005;135(1):81-95.

• van den Maagdenberg AM, Pietrobon D, Pizzorusso T, Kaja S, Broos LA, Cesetti T, van de Ven RC, Tottene A, van der Kaa J, Plomp JJ, Frants RR, Ferrari MD. A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron. 2004;41(5):701-10.

• Kaja S, Yang SH, Wei J, Fujitani K, Liu R, Brun-Zinkernagel AM, Simpkins JW, Inokuchi K, Koulen P. Estrogen protects the inner retina from apoptosis and ischemia-induced loss of Vesl-1L/Homer 1c immunoreactive synaptic connections. Invest Ophthalmol Vis Sci. 2003;44(7):3155-62.

Kaja S, Payne AJ, Burroughs SL, Koulen P. Homer. Encyclopedia of Signaling Molecules, Choi, Sangdun (Ed.), 1st Edition, 2013. ISBN 978-1-4419-0460-7.

http://www.springer.com/biomed/human+genetics/book/978-1-4419-0460-7

Kaja S. Synaptic effects of mutations in neuronal Cav2.1 calcium channels. 2007

Doctoral thesis; ISBN 9-78097819050-7.

https://openaccess.leidenuniv.nl/handle/1887/9750

Kaja S. Recent progress in migraine research. BNA Bulletin 2007, 56:20-22.

Citable abstracts

2011:

• S. Kaja, J.D. Hilgenberg, P. Koulen. Polycystin-2 In Mouse Lacrimal Gland Acinar Cells. ARVO Meeting Abstracts April 22, 2011 52:3716.

• P. Koulen, O.A. Mafe, R.S.Duncan, S. Kaja. Functional and Structural Protection by N-Acylethanolamines in Diabetic Retinopathy. ARVO Meeting Abstracts April 22, 2011 52:3937

2010:

• S. Kaja, R.S. Duncan, P. Garg, S.L. Burroughs, P. Koulen. Neuroprotection by N-linoleoylethanolamine in vitro and in vivo. Society for Neuroscience Annual Meeting 2010, San Diego, CA, Nov 16-21, 2010. Poster presentation.

• Payne, S. Kaja, S.-Y. Hwang, P. Koulen. Presenilin potentiates ryanodine receptor-mediated calcium release from intracellular stores. Society for Neuroscience Annual Meeting 2010, San Diego, CA, Nov 16-21, 2010. Slide presentation.

• R.S. Duncan, S. Kaja, J.D. Hilgenberg, J. Clark, P. Koulen. N-acylethanolamines activate transcription factors involved in neuroprotective signaling. Society for Neuroscience Annual Meeting 2010, San Diego, CA, Nov 16-21, 2010. Poster presentation.

• A.J. Payne, S. Kaja, and P. Koulen. Control of Ryanodine Receptor Mediated Calcium Signaling by Presenilins in Mouse Retinal Ganglion Cells. ARVO Meeting Abstracts April 11, 2010 51:1876. Poster presentation.

• S. Kaja, D. L. Goad, E. V. Gregg, M. D. Ferrari, A. M. J. M. Van den Maagdenberg, T. P. Snutch, and P. Koulen. Reduced Presynaptic Signaling in Retinal Neurons of a Transgenic Mouse Model for Familial Hemiplegic Migraine. ARVO Meeting Abstracts April 11, 2010 51:5796. Slide presentation.

2009:

• S. Kaja, R.S. Duncan, E.V. Gregg, D.L. Goad, P. Koulen. Type 2 inositol-1,4,5-trisphosphate (IP3) receptors mediate oxidative stress-induced increases of intracellular Ca2+ release. Society for Neuroscience Annual Meeting 2009, Chicago, IL, Oct 16-21, 2009. Poster presentation.

• P. Koulen, R.S. Duncan, S. Kaja, D.L. Goad. Potentiation of intracellular calcium release by gonadal steroid hormones in the central nervous system. Society for Neuroscience Annual Meeting 2009, Chicago, IL, Oct 16-21, 2009. Slide presentation.

• S. Kaja, D.L. Goad, E.S. Nixon, P. Koulen. Estrogen controls intracellular calcium signaling in the retina. Society for Neuroscience Annual Meeting 2009, Chicago, IL, Oct 16-21, 2009. Slide presentation.

• S. Kaja, E. Nixon, P. Koulen. Estrogen signaling in retinal neurons. Annual Meeting of the Association for Research in Vision and Ophthalmology 2009, Fort Lauderdale, FL, May 3-7, 2009. Poster presentation.

2002-2008:

• S. Kaja, J. Mezeyova, L. Qiu, R.S. Gopaul, A.M. Van den Maagdenberg, D. Parker, T.P. Snutch. Reduced expression of low-voltage activated calcium channels and GABA type A receptors in the cerebellum of familial hemiplegic migraine type 1 S218L knock-in mice. Society for Neuroscience Annual Meeting 2008, Washington, D.C., Nov 14-19, 2008. Poster presentation.

• S. Kaja, M. Shapovalova, A. Tottene, J. Mezeyova, D. Parker, M.D. Ferrari, A.M. van den Maagdenberg, D. Pietrobon, T.P. Snutch. Absence of Functional Compensation in Cerebellar Neurons of Knock-in Mice with the Familial Hemiplegic Migraine Type 1 S218L Mutation. Society for Neuroscience Annual Meeting San Diego, CA 2007. Slide presentation

• S.Kaja, R.C.G. Van de Ven, M.D. Ferrari, R.R. Frants, A.M.J. Van den Maagdenberg, J.J. Plomp. Differential non-Cav2.1 compensation profiles at motor nerve terminals of Leaner and Null Cav2.1-mutant mice. Society for Neuroscience Annual Meeting Atlanta, GA 2006. Slide presentation

• S. Kaja, R.C.G. Van de Ven, L.A.M. Broos, R.R. Frants, M.D. Ferrari, A.M.J. Van den Maagdenberg, J.J. Plomp Increased transmitter release at neuromuscular synapses of a novel Cacna1a S218L knock-in mouse model for familial hemiplegic migraine. Society for Neuroscience Annual Meeting San Diego, CA 2004. Slide presentation

• S. Kaja, A.M.J.M. van den Maagdenberg, L. Broos, R.C.G. van de Ven, M.D. Ferrari, R.R. Frants and J.J. Plomp. Neuromuscular Transmission is altered in a novel transgenic mouse model with the familial hemiplegic migraine type-1 R192Q mutation. British Neurosci. Abstr., vol 17, P28.05, 2003. Poster presentation

• S. Kaja, S. Yang, R. Liu, K. Fujitani, A.-M. Brun-Zinkernagel, J.H. Brandstatter, J.W. Simpkins, K. Inokuchi, P. Koulen. Loss of Vesl-1L/Homer-1c in the retina indicative of early neuronal changes following mild neuronal damage and protection by estrogen. British Neurosci. Abstr., vol 17, P56.12, 2003. Poster presentation

• S. Kaja, A. Wilton, M. Bingley, P. Tiwari, C.L. Thompson. Expression of cerebellar granule cell-specific GABA-A receptors is impaired in the epileptic and ataxic mouse, tottering. British Neurosci. Abstr., vol 17, P58.03, 2003. Poster presentation

• S. Kaja, S. Yang, R. Liu, K. Fujitani, A.-M. Brun-Zinkernagel, J.H. Brandstatter, J.W. Simpkins, K. Inokuchi, P. Koulen. Vesl-1L/Homer-1c expression in the rat retina and changed expression during retinal ischemia and neuroprotection by estrogen. Society for Neuroscience Annual Meeting Orlando, FL 2002. Slide presentation

Other abstracts

• S. Kaja, J.D. Hilgenberg, P. Koulen. Polycystin-2 In Mouse Lacrimal Gland Acinar Cells. UMKC Health Sciences Research Summit 2011.

• N.M. Desai, R.S. Duncan, J.D. Hilgenberg, S. Kaja, P. Koulen. Novel mechanism of calcium dysregulation after oxidative stress. UMKC Health Sciences Research Summit 2011

• Zabaneh, R.S. Duncan, P. Garg, S. Kaja, P. Koulen. Linoleoylethanolamide improves functional outcome in a model of stroke. UMKC Health Sciences Research Summit 2011.

• R.S. Duncan, S. Kaja, J.D. Hilgenberg, J. Clark, P. Koulen. N-Acylethanolamines Activate Transcription Factors Involved in Neuroprotective Signaling. UMKC Health Sciences Research Summit 2011.

• S.L. Burroughs, S. Kaja, P. Koulen. Quantification of deficits in spatial visual function of mouse models for glaucoma. UMKC Health Sciences Research Summit 2011.

• A.J. Payne, S. Kaja, P. Koulen. Control of Ryanodine Receptor Mediated Calcium Signaling by Presenilins in the in Mouse Retina Ganglion Cells. UMKC Health Sciences Research Summit 2011.

• N.M. Desai, S. Kaja, P. Koulen. Novel mechanism of calcium dysregulation after oxidative stress. UMKC School of Medicine, Student Research Day 2011.

• Zabaneh, R.S. Duncan, P. Garg, S. Kaja, P. Koulen. Lauroylethanolamide and linoleoylethanolamide improve functional outcome in a model of stroke. UMKC School of Medicine, Student Research Day 2011.

• S. Kaja, J. Mezeyova, E.O. Nielsen, N.R. Mirza, D. Parker, T.P. Snutch. GABA type-A receptors in the cerebellum of familial hemiplegic migraine type 1 S218L knock-in mice. European Molecular Biology Organization US Fellows Meeting 2008, Boston, MA, November 7-9, 2008. Slide and poster presentation.

• S. Kaja, J. Mezeyova, D. Parker, T.P. Snutch. Reduced Cav3.1 Calcium Channel Expression in the Cerebellum of Knock-in Mice with the Familial Hemiplegic Migraine Type 1 S218L Mutation. European Molecular Biology Organization Fellows Meeting 2008, Heidelberg, Germany; June 12-15, 2008. Slide and poster presentation.

• S. Kaja, J. Mezeyova, D. Parker, T.P. Snutch. Migraine: insights from two novel transgenic mouse models. The Chris Thompson Memorial Symposium / Neuroscience North East, Durham, United Kingdom, April 8-9, 2008. Slide presentation.

• S. Kaja, E. Gregg, L.S. David, J.J. Plomp, A.M. van den Maagdenberg, P. Koulen, T.P. Snutch. Altered expression of calcium channels in retinae of transgenic knock-in mice with the familial hemiplegic migraine mutation R192Q in Cacna1a. EMBO Fellows USA Meeting 2006, Nov11-13, Salk Institute, La Jolla, CA. Poster presentation.

• S. Kaja, R.C. van de Ven, R.R. Frants, M.D. Ferrari, A.M. Van den Maagdenberg, J.J. Plomp. Characterization of neuromuscular synaptic transmission in the novel Cacna1a S218L knock-in mouse model for familial hemiplegic migraine. Postgraduate and Early-Career Symposium 2005, Sep 14-15, Durham, UK. Slide presentation.

• S. Kaja, R.C. van de Ven, R.R. Frants, M.D. Ferrari, A.M. Van den Maagdenberg, J.J. Plomp. Neuromuscular synaptic characterization of a novel cacna1a knock-in mouse with the FHM1 S218L mutation. Endo-Neuro-Psycho Meeting 2005, June 2, Doorweerth, The Netherlands. Poster presentation.

• S. Kaja, R.C. van de Ven, L.A. Broos, H. Veldman, J.G. van Dijk, J.H. Wokke, R.R. Frants, M.D. Ferrari, J.J. Verschuuren, A.M. van den Maagdenberg, J.J. Plomp. Familial Hemiplegic Migraine Type-1 R192Q Knock-In Mice Exhibit Altered Neuromuscular Synaptic Transmission. Endo-Neuro-Psycho Meeting 2004, June 1-4, 2004, Doorwerth, The Netherlands. Poster presentation.

• A.M. Van den Maagdenberg, J.J. Plomp, L.A.M. Broos, S. Kaja, R.C. Van de Ven, M.D. Ferrari, R.R. Frants. A novel transgenic mouse model with the R192Q Familial Hemiplegic Migraine mutation: generation and preliminary (electrophysiological) characterization. The 2003 European Human Genetics Conference 2003, May 3-6, Birmingham, UK. Poster presentation.

• S. Kaja, S. Yang, R. Liu, A.M. Brun-Zinkernagel, J.W. Simpkins, P. Koulen. Loss of Vesl-1L/Homer-1c in the retina indicative of early neuronal changes following mild neuronal damage and protection by estrogen. International Symposium “Molecular Basis of CNS Disorders” 2003, February 20-22, Bonn, Germany. Poster presentation.

• S. Kaja, J.J. Plomp, L.A. Broos, R.C. van de Ven, A.M. van den Maagdenberg, R.R. Frants, M.D. Ferrari. Ex vivo electrophysiology at the mouse neuromuscular junction. Topiramate Preclinical Update Meeting Johnson & Johnson 2003, Jan 16-18, Coral Gables, FL. Slide presentation.

• S. Kaja, A. Wilton, M. Bingley, P. Tiwari, C.L. Thompson. Expression of an extrasynaptic, cerebellar granule cell-specific GABA-A receptor subtype is selectively impaired in the epileptic and ataxic mouse, Tottering. Neuroscience North East Conference 2002, Dec 16-17, Sunderland, UK. Slide presentation.

Smartphones in Ophthalmology

* Workshop: “Smartphones in Ophthalmology”. Association for Research in Vision and Ophthalmology Annual Meeting 2011, Fort Lauderdale, FL. Program #326

Organizers: Shah VA and Kaja S.

* Skills Transfer Lab: “The iPhone for Ophthalmologists”. American Academy of Ophthalmology Annual Meeting 2010, Chicago, IL, Program #LAB161

Course DIrector: Shah VA; Instructor: Kaja, S.

* Special Interest Group: “Smartphones in Ophthalmology”. Association for Research in Vision and Ophthalmology Annual Meeting 2010, Fort Lauderdale, FL. Program #487

Organizers: Shah VA, Lord RK and Kaja S.